Table 3.

Comparison of liposomes and extracellular vesicles (EVs).

Vehicle	Advantages	Disadvantages	Reference
Liposomes	- Various sizes with either single or multiple lipid bilayer - Diversity of lipid compositions - Mass production - Active clinical research	- Potential complement activation and low cellular uptake - Insufficient drug loading - Premature drug release	[107] [108]
Extracellular Vesicles	- Structurally similarity comparable to other membranous structures found in cells - Membrane-associated proteins, receptors, adhesion molecules, as well as a natural corona - Natural characteristics to deliver molecules to target cells - Non-immunogenic	- Limited clinical trials because of uncertainties regarding EVs - Necessity to establish methods for stable production and bulk preparation