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(A) Pro-apoptotic BH3 (only) or Bax/Bak-like proteins’ sequestration by anti-apoptotic Bcl-2-like proteins leads to cell survival. (B) BH3 (only)-proteins respond to cell stress provoked by chemo-therapeutic agents (Table 1) by binding to and inactivating anti-apoptotic Bcl-2-like proteins. BH3-only proteins can also engage Bax/Bak, causing their conformational transformation, activation and mitochondrial outer membrane destabilization [90].
