Table 7.
Preclinical activities of BH3 mimetics [104].
| Inhibitor | Cancer Models |
|---|---|
| HA14-1 and derivatives | Lymphoma, leukemia, myeloma, glioma, ovarian, prostate |
| BH3Is | Leukemia, cervical, glioma |
| 2-Methoxy-antimycin A3 | Lung, mesothelioma, esophageal |
| (-)-Gossypol | Lymphoma1, leukemia2, myeloma3, prostate, colon, head and neck squamous cell carcinoma |
| TW-37 | Lymphoma, leukemia, prostate, lung, pancreatic, liver, nasopharyngeal |
| Apogossypolone and derivatives | Lymphoma, leukemia, prostate, lung, pancreatic, liver, nasopharyngeal |
| BI-97CI | Lymphoma, prostate, lung |
| Chelerythrine | Leukemia, liver, cardiac, neuroblastoma |
| YC137 | Breast |
| Obatoclax | Lymphoma, leukemia, myeloma, lung, mammary carcinoma, colon, cervical, prostate |
| ABT-737/263 | Lymphoma, leukemia, myeloma, prostate, lung, pancreatic, ovarian, colorectal, gastrointestinal |
| S1 | Breast, liver, cervical |