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. 2018 Dec 18;19(12):4105. doi: 10.3390/ijms19124105

Figure 5.

Figure 5

Chronic treatment with ISO-1 and compound 31 prevents the recruitment of perivascular macrophages in the lungs of bleomycin (BLM)-injected mice. (A) Representative images of F4/80 (white arrowhead) with α-smooth muscle actin (α-SMA; green) immunostaining and DAPI (blue) around vessels in lungs of BLM-injected mice treated, or not, with ISO-1 or compound 31. (B) Levels of circulating CCL2 proteins in the serum of BLM-injected mice compared to those of control mice. Values are means ± SEM (n = 4–8), where n represents the number of mice. * p < 0.05; *** p < 0.001 compared to control mice. ## p < 0.05; ### p < 0.01 compared to BLM-injected mice. Scale bar = 20 μm in all sections. α-SMA = α-smooth muscle actin; AU = arbitrary unit.