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. 2018 Dec 3;19(12):3848. doi: 10.3390/ijms19123848

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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SPS and drugs (OXT and ASB) changed the mRNA expression of central IL-1β. Medial prefrontal cortex (mPFC) IL-1β levels were increased following SPS, which could not be reversed by OXT (A). OXT reversed SPS-elevated IL-1β levels in hippocampus, and ASB further blocked the OXT effect (B). SPS and drugs had no effect on amygdala IL-1β levels (C). n = 5 for each group; SPS = single prolonged stress, Veh = vehicle, OXT = oxytocin, ASB = atosiban, OXTR = oxytocin receptor. Bars represent mean ± SEM; * p < 0.05, ** p < 0.01, *** p < 0.001.