Table 3.
Mean 2-hydroxybenzylamine pharmacokinetic parameters after a single oral dose
| Parameter | 2-Hydroxybenzylamine acetate dose | |||||
|---|---|---|---|---|---|---|
| 50 mg (n = 3) | 100 mg (n = 3) | 200 mg (n = 3) | 330 mg (n = 3) | 550 mg (n = 3) | 825 mg (n = 3) | |
| Half-life (h) | 2.04 | 2.33 | 2.03 | 1.77 | 2.32 | 2.13 |
| Cmax (ng/mL) | 90 | 156 | 369 | 669 | 1636 | 2510 |
| tmax (h) | 1.33 | 1.33 | 1.83 | 1.67 | 1.67 | 1.67 |
| AUC (h·ng/mL) | 396 | 622 | 1490 | 2690 | 4417 | 9053 |
| AUCextrap (%) | 9.1 | 11.2 | 10.0 | 8.2 | 11.2 | 10.3 |
Cmax maximum observed plasma concentration, tmax time to reach, Cmax AUC, area under the concentration-time curve from zero to infinity, AUCextrap percentage of the AUC extrapolated from the last observed time point
Clearance and volume of distribution are not reported due to the unknown value of F (bioavailability)