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. 2019 Jan 5;11:1. doi: 10.1186/s13148-018-0606-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Manhattan and QQ plots showing epigenome-wide associations from discovery analysis. a QQ plot showing observed versus expected − log₁₀(P) for association at all loci. b Manhattan plot showing chromosomal locations of − log₁₀(P) for association at each locus. All CpG sites with FDR < 0.05 are highlighted in green and the top gene for each of the highlighted loci is labeled