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. 2019 Jan 5;20:3. doi: 10.1186/s12931-018-0962-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Formation of exonic circRNAs (EcircRNAs), exon-intron circRNAs (EIciRNAs), and intronic circRNAs (CiRNAs). Two models of EcircRNAs and EIciRNAs formation exist, including lariat-driven circularization and intron-pairing-driven circularization, which can be catalyzed by complementary sequences and RNA-binding proteins (RBPs). CiRNA formation depends mainly on consensus motifs near both ends