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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Heart Rhythm. 2018 Aug 1;16(1):108–116. doi: 10.1016/j.hrthm.2018.07.036

Fig. 1. Effects of chronic Ang II administration on guinea pig hearts.

Fig. 1

(A) Heart-to-body weight ratio was modestly elevated in animals implanted with vehicle-containing minipump, but markedly increased in those implanted with Ang II-containing minipump, relative to age-matched control (Veh, Ang and CON, respectively). (B) Ang II animals showed marked increase in interstitial fibrosis in both atria and ventricles, relative to Veh animals. Top: Images of Masson’s trichrome stain. Bottom: Quantification of % of fibrotic area in the samples. N=number of hearts examined. * p < 0.001, Ang II vs Veh. (C) Left ventricular ejection fraction (LVEF) dropped in Ang II, but not Veh, animals. Different symbols linked by lines represent different animals before and 2 weeks after minipump implantation.