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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Heart Rhythm. 2018 Aug 1;16(1):108–116. doi: 10.1016/j.hrthm.2018.07.036

Fig. 5. Effects of chronic Ang II administration on action potential duration, plateau voltage, and outward IK1 current densities of guinea pig atrial and ventricular myocytes.

Fig. 5

(A) Superimposed action potential traces (APs) recorded from 8–10 each of 4 groups of myocytes. Cycle length (CL) was 1 s. Dashed horizontal lines denote 0 and −60 mV. Arrowheads and dotted vertical lines denote the time point when plateau voltages were measured. (B) Action potential duration (APD) measured as interval between upstroke and when membrane voltage repolarized to −60 mV. (C) Plateau voltage measured as voltage 20 ms (GPA) or 50 ms (GPV) after the upstroke. (D) IK1 current density based on the highest value of outward IK1 current (typically at −50 mV), normalized by cell capacitance. Numbers of myocytes studied are listed (from 7 each of Veh and Ang II animals). * t-test, Ang II vs Veh, p < 0.05.