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. 2018 Mar 20;10(1):43–59. doi: 10.1007/s13238-018-0512-0

Figure 8.

Figure 8

Model of Fir1 mechanisms in regeneration. (A) Model of Fir1 function in regeneration. Fir1, a neoblast-enriched regulator, controls regenerative proliferation. (B) A proposed genetic model for Fir1 in regeneration. Once a missing-tissue injury occurs, Fir1+ cells at the wound sites acquire wound and regenerative signal, sense regeneration on demand. Then Fir1 promotes the expression of Dis3l2, which triggers local proliferation, and generate sufficient neoblast for sequential regeneration