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. 2018 Sep 11;68(2):229–238. doi: 10.1093/cid/ciy454

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Published by Oxford University Press for the Infectious Diseases Society of America 2018.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 4. — Changes in spleen ¹⁸F-fluorodeoxyglucose (FDG) uptake in representative non–immune reconstitution inflammatory syndrome (IRIS) and IRIS patients. A, A 26-year-old male non-IRIS subject (non-IRIS-05) showing decreased spleen FDG uptake (black arrows) after antiretroviral therapy (ART) on coronal reconstruction positron emission tomography images of the upper abdomen. This is reflected as 45% decrease in mean standardized uptake (SUV_mean) and 36% decrease in maximum standardized uptake (SUV_max) values with respect to baseline. B, A 37-year-old male IRIS subject (IRIS-01) with paradoxical mycobacterial IRIS showing slightly increased spleen FDG uptake (black arrows) after ART initiation with 22% increase in SUV_mean and 19% increase in SUV_max values with respect to baseline. Abbreviations: ART, antiretroviral therapy; IRIS, immune reconstitution inflammatory syndrome; SUV_max, maximum standardized uptake value; SUV_mean, mean standardized uptake value.