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. 2018 Sep 25;4(11):e000222. doi: 10.1099/mgen.0.000222

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© 2018 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 6. — Models of HR following transformation in N. meningitidis. Model I shows fragmentation (e.g. by endonuclease digestion of DNA - e) of the transformed DNA prior to recombination, resulting in HR of two fragments (f) flanking a non-recombined region (u). Model II shows interruptions (i) in the recombination mechanism resulting in interspersed integration of DNA. Model III shows how secondary recombination of self-DNA (s) may introduce a region (u) without the SNVs in the original recombination pattern. Model IV shows how strand-dependent MMR (r) following recombination can introduce non-recombined regions (u) in the original recombination pattern – asynchronous heteroduplex segregation of the donor region on one strand (h) during DNA replication may also introduce non-recombined regions.