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. 2019 Jan 3;39(2):e00271-18. doi: 10.1128/MCB.00271-18

FIG 6.

FIG 6

Brc1 and the Nse5-Nse6 dimer are required for the accumulation of the Smc5-Smc6 complex in foci or on chromatin during replication stress and for the Nse2-dependent SUMOylation of its subunits, e.g., Nse4. Brc1 physically interacts with Nse5-Nse6, as well as gamma-H2A, so it can tether Smc5-Smc6 at replicative DNA lesions. It is likely that other proteins at collapsed replication forks in the vicinity of Smc5-Smc6-Nse2 foci also undergo SUMOylation.