TABLE 2.
Functional enrichment analysis of CVS proteome in live HSV-2-inoculated RM
| Function type and term | Count | P value | Bonferroni | Genes |
|---|---|---|---|---|
| Functions associated with proteins differentially expressed on day 1 relative to baseline (day 0) | ||||
| Response to wounding | 31 | 1.51E−13 | 6.97E−11 | A2M, C3, C6, C5, PRDX2, PF4, AHSG, FGG, FGA, FGB, FCN2, RAC1, SERPINC1, CFH, KRT1, APOH, VNN1, SERPINA1, THBS1, KLK6, APCS, C4A, SAA4, C4BPA, ANXA5, SERPINB2, DSP, LTA4H, SERPIND1, IL1F6, PROS1 |
| Defense response | 24 | 3.50E−07 | 1.62E−04 | A2M, APCS, C4A, C3, S100A7, C6, C5, SAA4, PRDX2, CD5L, HP, C4BPA, COTL1, AHSG, FCN2, RAC1, KRT1, CFH, LTF, VNN1, LTA4H, SERPINA1, THBS1, IL1F6 |
| Regulation of immune system process | 18 | 1.48E−06 | 6.84E−04 | A2M, C4A, C3, IL6ST, C6, C5, PF4, PRDX2, C4BPA, AMBP, APOA1, HPX, FCN2, CFH, KRT1, VNN1, CA2, THBS1 |
| Blood coagulation | 10 | 2.09E−06 | 9.65E−04 | FGG, FGA, FGB, APOH, SERPINC1, PF4, SERPINA1, SERPIND1, ANXA5, PROS1 |
| Humoral immune response | 9 | 2.77E−06 | 1.28E−03 | C4A, C3, FCN2, C6, C5, CFH, KRT1, LTF, C4BPA |
| Regulation of immune response | 13 | 8.99E−06 | 4.16E−03 | AMBP, A2M, APOA1, C4A, HPX, IL6ST, C3, FCN2, C6, C5, KRT1, CFH, C4BPA |
| Carbohydrate catabolic process | 9 | 3.04E−05 | 1.40E−02 | GNS, TPI1, GM2A, PGD, PGAM1, BPGM, GAPDH, MDH1, ENO1 |
| Functions associated with proteins differentially expressed on day 2 relative to baseline (day 0) | ||||
| Inflammatory response | 17 | 1.12E−08 | 7.48E−06 | TF, A2M, APCS, C4A, C3, C6, C5, SAA4, PRDX2, C1S, AHSG, FCN2, KRT1, CFH, VNN1, SERPINA1, THBS1 |
| Carbohydrate catabolic process | 10 | 3.01E−07 | 2.02E−04 | TPI1, GM2A, NUDT5, PGD, MGAM, PGAM1, BPGM, GAPDH, MDH1, ENO1 |
| Blood coagulation | 9 | 2.09E−06 | 1.40E−03 | FGG, FGA, FGB, APOH, SERPINC1, SERPINA1, SERPIND1, ANXA5, PROS1 |
| Regulation of immune response | 12 | 2.85E−06 | 1.91E−03 | AMBP, A2M, APOA1, C4A, C3, HPX, FCN2, C6, C5, CFH, KRT1, C1S |
| Epidermis development | 11 | 6.24E−06 | 4.17E−03 | KRT6A, KRT17, KRT5, KRT16, KRT15, KRT1, ALOX12B, DSP, KRT13, KRT2, KRT10 |
| Response to metal ion | 9 | 1.21E−05 | 8.05E−03 | ACTB, FGG, APOB, FGA, FGB, ANXA11, SERPINA1, CA2, THBS1 |
| Wound healing | 10 | 3.09E−05 | 2.05E−02 | FGG, FGA, FGB, APOH, SERPINC1, DSP, SERPINA1, SERPIND1, ANXA5, PROS1 |
| Functions associated with proteins differentially expressed on day 29 relative to baseline (day 0) | ||||
| Response to wounding | 25 | 6.32E−12 | 2.60E−09 | TF, A2M, C3, C5, PF4, PRDX2, C1S, AHSG, FGG, FGA, FGB, KRT1, SERPINC1, VNN1, SERPINA1, THBS1, APCS, C4A, C4BPA, ANXA5, VWF, DSP, SERPIND1, IL1F6, PROS1 |
| Blood coagulation | 10 | 1.53E−07 | 6.30E−05 | VWF, FGG, FGA, FGB, SERPINC1, PF4, SERPINA1, SERPIND1, ANXA5, PROS1 |
| Defense response | 19 | 2.62E−06 | 1.07E−03 | TF, A2M, APCS, C4A, C3, S100A7, C5, CD5L, HP, PRDX2, C4BPA, C1S, COTL1, AHSG, KRT1, VNN1, SERPINA1, THBS1, IL1F6 |
| Regulation of immune system process | 14 | 1.66E−05 | 6.80E−03 | A2M, APOA1, C4A, HPX, C3, C5, KRT1, VNN1, PRDX2, PF4, CA2, C1S, C4BPA, THBS1 |
| Complement activation | 6 | 2.32E−05 | 9.50E−03 | C4A, C3, C5, KRT1, C1S, C4BPA |
| Tissue development | 17 | 1.07E−04 | 4.30E−02 | MYL6, KRT6A, S100A7, KRT13, KRT10, SCEL, FGA, KRT16, KRT15, AGT, KRT1, ALOX12B, DSP, KRT2, KRT3, KRT4, CA2 |