FIG 8.

(A) Viral growth in 4T1 tumors. Tumors treated with PBS, Δγ₁34.5, ΔN146, and EUs11 suspended in PBS were collected on day 9, and infectious viruses present in tumors were quantified by plaque assay (n = 6). (B) Hematoxylin and eosin (H&E) and immunostaining showing the HSV-1 antigens in the tumors. (C) Quantification PCR analysis of HSV-1 DNA in blood, liver, and spleen (n = 6). All the data are representative of those from three experiments. Differences between the selected groups were statistically assessed by a two-tailed Student t test. **, P < 0.01.