TABLE 1.

Thermodynamic properties of bile acids binding to norovirus P domains and VLPs^a

Binding partner	Bile acid	Mean ΔH (cal/mol) ± SD	Mean ΔS (cal/mol/degrees K) ± SD	Mean Kd (M) ± SD
GII.1 P domain	GCDCA	−1.6E+04 ± 1E+3	−23.03 ± 4	3.6E−07 ± 3E−8
	GCA	−1.6E+04 ± 2E+2	−25.63 ± 1	5.8E−07 ± 5E−8
	TCDCA	−1.7E+04 ± 3E+3	−28.50 ± 10	4.3E−07 ± 9E−8
	TCA	−1.7E+04 ± 3E+2	−29.33 ± 1	6.1E−07 ± 1E−7
GII.10 P domain	GCDCA	−1.0E+04 ± 3E+3	−10.32 ± 10	7.2E−06 ± 2E−6
	GCA	−1.3E+04 ± 1E+2	−20.13 ± 0.3	5.5E−06 ± 2E−8
	TCDCA	−1.2E+04 ± 1E+3	−16.57 ± 5	12.3E−06 ± 8E−7
	TCA	−1.3E+04 ± 2E+3	−20.10 ± 6	10.3E−06 ± 2E−7
GII.10 VLPs	GCDCA	−1.0E+04 ± 1E+2	−9.03 ± 1	6.1E−06 ± 9E−7
GII.19 P domain	GCDCA	−1.4E+04 ± 4E+2	−20.26 ± 2	1.2E−06 ± 1E−7
GI.1 VLPs/P domain	GCDCA	NB	NB	NB
GII.3 P domain	GCDCA	NB	NB	NB
GII.4 VLPs/P domain	GCDCA	NB	NB	NB
GII.17 P domain	GCDCA	NB	NB	NB

^aNB, no binding.