Table 1.
Clinical events: primary and secondary endpoints
| Estimated cumulative incidence at 5 years |
Hazard ratio (95% CI) | P-value | ||
|---|---|---|---|---|
| FFR-guided PCI | Medical therapy | |||
| Cardiac death or MIa | 10.7% (8.4–13.6%) | 16.4% (13.3–20.1%) | 0.72 (0.54–0.96) | 0.02 |
| Death or MI | 13.9% (11.2–17.2%) | 19.4% (16.0–23.4%) | 0.76 (0.59–0.99) | 0.04 |
| MI | 8.5% (6.5–11.1%) | 13.4% (10.7–16.8%) | 0.70 (0.51–0.97) | 0.03 |
| Cardiac death | 3.2% (2.1–5.1%) | 3.0% (1.9–4.8%) | 1.04 (0.58–1.78) | 0.89 |
| All-cause mortality | 7.0% (5.2–9.6%) | 6.5% (4.7–8.9%) | 1.03 (0.69–1.54) | 0.89 |
a
Pre-specified primary outcome. FFR-guided PCI (N = 1056) and medical therapy (N = 1344).
CI, confidence interval; FFR, fractional flow reserve; MI, myocardial infarction; PCI, percutaneous coronary intervention.