Table 2.
Changes in quantitative computer-aided diagnosis scores from baseline, by treatment arm and pooled group
| Cyclophosphamide (n = 47) |
Mycophenolate Mofetil (n = 50) |
Pooled (N = 97) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline Mean (±SE) | 24 Mo Mean (±SE) | Mean Difference (95% CI) | Adjusted Mean Difference (95% CI) | Baseline Mean (±SE) | 24 Mo Mean (±SE) | Mean Difference (95% CI) | Adjusted Mean Difference (95% CI) | Baseline Mean (±SE) | 24 Mo Mean (±SE) | Mean Difference (95% CI) | Adjusted Mean Difference (95% CI) | |
| Whole lung | |
|
|
|||||||||
| QLF | 8.71 (±1.06) | 8.48 (±1.08) | −0.23 (−1.15 to 1.62) | −0.23 (−0.67 to 0.21) | 7.80 (±0.97) | 8.01 (±0.95) | 0.21 (−0.85 to 1.27) | 0.21 (−1.44 to 1.87) | 8.24 (±0.72) | 8.24 (±0.72) | −0.003 (−0.012 to 0.01) | −0.003 (−0.012 to 0.01) |
| QGG | 21.12 (±1.40) | 18.72 (±1.43) | −2.41 (−4.37 to −0.45)* | −2.41 (−4.31 to −0.50)* | 17.98 (±1.08) | 15.29 (±1.07) | −2.69 (−4.40 to −0.98)* | −2.69 (−4.35 to −1.03)* | 19.50 (±0.89) | 16.95 (±0.90) | −2.55 (−3.82 to −1.28)* | −2.55 (−3.80 to −1.30)* |
| QILD | 29.95 (±2.03) | 27.30 (±2.15) | −2.66 (−5.02 to −0.30)* | −2.66 (−4.96 to −0.36)* | 25.82 (±1.81) | 23.44 (±1.76) | −2.38 (−4.66 to −0.10)* | −2.87 (−4.31 to −1.42)* | 27.82 (±1.37) | 25.31 (±1.39) | −2.51 (−4.30 to −0.73)* | −2.52 (−4.00 to −1.03)* |
| Most severe lobe | |
|
|
|||||||||
| QLF | 23.01 (±3.19) | 23.32 (±3.39) | 0.31 (−2.92 to 3.55) | 0.31 (−2.83 to 3.47) | 22.41 (±2.94) | 24.17 (±3.08) | 1.76 (−1.24 to 4.75) | 1.76 (−1.16 to 4.68) | 22.70 (±2.15) | 23.76 (±2.27) | 1.06 (−1.11 to 3.22) | 1.05 (−1.08 to 3.17) |
| QGG | 26.90 (±1.82) | 24.34 (±1.73) | −2.56 (−4.61 to −0.50)* | −2.56 (−4.67 to −0.44)* | 26.46 (±1.36) | 23.12 (1.42) | −3.35 (−5.87 to −0.82)* | −3.35 (−5.80 to −0.88)* | 26.67 (±1.12) | 23.71 (±1.11) | −2.96 (−4.59 to −1.34)* | −2.96 (−4.57 to −1.35)* |
| QILD | 50.1 (±3.19) | 47.96 (±3.52) | −2.16 (−5.86 to 1.54) | −2.16 (−5.76 to 1.44) | 48.94 (±3.06) | 47.51 (±3.31) | −1.43 (−4.32 to 1.46) | −1.43 (−3.55 to 0.69) | 49.51 (±2.20) | 47.72 (±2.40) | −2.51 (−4.88 to −0.14)* | −2.51 (−4.19 to −0.13)* |
Definition of abbreviations: CI = confidence interval; QGG = quantitative ground glass; QILD = quantitative interstitial lung disease; QLF = quantitative lung fibrosis; SE = standard error.
The modified Rodnan skin score 95% CI was rescaled after transformation to meet the normality assumption.
*
P < 0.05.