Table 3.
Spearman correlation coefficients for changes in quantitative high-resolution computed tomography scores and changes in other physiological and clinical outcome measures at 24 months compared with baseline
| Whole Lung (N = 97) |
Most Severe Lobe (N = 97) |
|||
|---|---|---|---|---|
| QLF | QILD | QLF | QILD | |
| FVC percent predicted | −0.43 (P < 0.001) | −0.37 (P < 0.001) | −0.49 (P < 0.001) | −0.45 (P < 0.001) |
| DlCO percent predicted* | −0.09 (P = 0.42) | −0.22 (P = 0.04) | −0.03 (P = 0.79) | −0.17 (P = 0.10) |
| Percent changes in TLC | −0.33 (P < 0.001) | −0.36 (P < 0.001) | −0.35 (P < 0.001) | −0.34 (P < 0.001) |
| Dyspnea (TDI)† | −0.16 (P = 0.17) | −0.26 (P = 0.03) | −0.07 (P = 0.54) | −0.20 (P = 0.08) |
| mRSS | 0.08 (P = 0.44) | 0.09 (P = 0.37) | 0.09 (P = 0.39) | 0.03 (P = 0.74) |
Definition of abbreviations: DlCO = diffusing capacity of the lung for carbon monoxide; FVC = forced vital capacity; mRSS = modified Rodnan skin score; QILD = quantitative interstitial lung disease; QLF = quantitative lung fibrosis; TDI = Transition Dyspnea Index on 7-point scale from −3 (major deterioration) to +3 (major improvement); TLC = total lung capacity.
*
n = 93.
†
n = 72.