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. 2018 Dec;15(12):1411–1419. doi: 10.1513/AnnalsATS.201802-150OC

Table 3.

Relationship between vapors, gas, dust, or fumes exposure in the longest job and computed tomographic measures of airway remodeling and lung parenchyma in current and former smokers

Current and Former Smokers (n = 2,736) Longest Job Exposure
Longest Job Exposure (Adjusted for Age, Sex, Race, Current Smoking Status, Pack-Years of Smoking, BMI, Study Site)
  β CI P Value β CI P Value
Emphysema
 % emphysema 1.11 0.33 to 1.89 0.01 1.17 0.44 to 1.89 0.002
Large airway
 Pi10 (whole lung) 0.011 0.005 to 0.017 <0.001 0.008 0.002 to 0.014 0.01
 Wall area %*            
  Segmental 0.475 0.312 to 0.637 <0.001 0.487 0.320 to 0.654 <0.001
  Subsegmental 0.346 0.223 to 0.468 <0.001 0.400 0.275 to 0.527 <0.001
 Airway lumen area*            
  Segmental −0.107 −0.505 to 0.291 0.60 0.652 1.060 to0.244 0.002
  Subsegmental −0.577 −1.226 to 0.071 0.08 −0.846 −1.521 to −0.170 0.01
 Airway wall area*            
  Segmental 0.618 0.291 to 0.944 <0.001 −0.156 −0.481 to 0.169 0.35
  Subsegmental 0.058 −0.189 to 0.306 0.64 −0.297 −0.549 to −0.045 0.02
Small airway
 % air trapping 1.53 −0.11 to 3.16 0.07 2.6 1.11 to 4.09 0.001
 % PRM fSAD 0.41 −0.81 to 1.64 0.51 1.45 0.31 to 2.60 0.01

Definition of abbreviations: BMI = body mass index; CI = confidence interval; Pi10 = estimated square-root wall area of a single hypothetical airway with internal perimeter of 10 mm; PRM fSAD = parametric response mapping of functional small-airway abnormality.

*

Additionally adjusted for lung volume.

Boldface entries indicate a statistically significant association with P < 0.005.