Table 3.
Relationship between vapors, gas, dust, or fumes exposure in the longest job and computed tomographic measures of airway remodeling and lung parenchyma in current and former smokers
| Current and Former Smokers (n = 2,736) | Longest Job Exposure |
Longest Job Exposure (Adjusted for Age, Sex, Race, Current Smoking Status, Pack-Years of Smoking, BMI, Study Site) |
||||
|---|---|---|---|---|---|---|
| β | CI | P Value | β | CI | P Value | |
| Emphysema | ||||||
| % emphysema | 1.11 | 0.33 to 1.89 | 0.01 | 1.17 | 0.44 to 1.89 | 0.002 |
| Large airway | ||||||
| Pi10 (whole lung) | 0.011 | 0.005 to 0.017 | <0.001 | 0.008 | 0.002 to 0.014 | 0.01 |
| Wall area %* | ||||||
| Segmental | 0.475 | 0.312 to 0.637 | <0.001 | 0.487 | 0.320 to 0.654 | <0.001 |
| Subsegmental | 0.346 | 0.223 to 0.468 | <0.001 | 0.400 | 0.275 to 0.527 | <0.001 |
| Airway lumen area* | ||||||
| Segmental | −0.107 | −0.505 to 0.291 | 0.60 | −0.652 | −1.060 to −0.244 | 0.002 |
| Subsegmental | −0.577 | −1.226 to 0.071 | 0.08 | −0.846 | −1.521 to −0.170 | 0.01 |
| Airway wall area* | ||||||
| Segmental | 0.618 | 0.291 to 0.944 | <0.001 | −0.156 | −0.481 to 0.169 | 0.35 |
| Subsegmental | 0.058 | −0.189 to 0.306 | 0.64 | −0.297 | −0.549 to −0.045 | 0.02 |
| Small airway | ||||||
| % air trapping | 1.53 | −0.11 to 3.16 | 0.07 | 2.6 | 1.11 to 4.09 | 0.001 |
| % PRM fSAD | 0.41 | −0.81 to 1.64 | 0.51 | 1.45 | 0.31 to 2.60 | 0.01 |
Definition of abbreviations: BMI = body mass index; CI = confidence interval; Pi10 = estimated square-root wall area of a single hypothetical airway with internal perimeter of 10 mm; PRM fSAD = parametric response mapping of functional small-airway abnormality.
*
Additionally adjusted for lung volume.
Boldface entries indicate a statistically significant association with P < 0.005.