Table 5.
Relationship between vapors, gas, dust, or fumes exposure in the longest job and computed tomographic measures of airway remodeling and lung parenchyma in spirometry-confirmed chronic obstructive pulmonary disease
| Spirometry-confirmed COPD (n = 1,809) | Longest Job Exposure (Adjusted for Age, Sex, Race, Current Smoking Status, Pack-Years of Smoking, BMI, Study Site) |
||
|---|---|---|---|
| β | CI | P value | |
| Emphysema | |||
| % emphysema | 0.76 | −0.21 to 1.74 | 0.12 |
| Large airway | |||
| Pi10 (whole lung) | 0.003 | −0.005 to 0.011 | 0.43 |
| Wall area %* | |||
| Segmental | 0.302 | 0.098 to 0.506 | 0.004 |
| Subsegmental | 0.321 | 0.164 to 0.479 | <0.001 |
| Airway lumen area* | |||
| Segmental | −0.379 | −0.875 to 0.118 | 0.14 |
| Subsegmental | −1.025 | −2.087 to 0.037 | 0.06 |
| Airway wall area* | |||
| Segmental | −0.062 | −0.409 to 0.397 | 0.98 |
| Subsegmental | −0.371 | −0.704 to −0.038 | 0.03 |
| Small airway | |||
| % air trapping | 2.05 | 0.23 to 3.87 | 0.03 |
| % PRM fSAD | 1.32 | −0.02 to 2.67 | 0.05 |
Definition of abbreviations: BMI = body mass index; CI = confidence interval; COPD = chronic obstructive pulmonary disease; Pi10 = estimated square-root wall area of a single hypothetical airway with internal perimeter of 10 mm; PRM fSAD = parametric response mapping of functional small-airway abnormality.
*
Additionally adjusted for lung volume.
Boldface entries indicate a statistically significant association with P < 0.005.