Table 1.
Association results with IHPS in discovery (Denmark), replication (Sweden and US—non-Hispanic Whites) and combined analysis
| Alleles | Frequency | Number | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Position | A1 | A2 | Cohort | Cases | Controls | Cases | Controls | OR (95% CI) | P | Q |
| rs6736913 | 2:42510018 | A | G | Discovery | 0.045 | 0.019 | 1395 | 4438 | 2.42 (2.17–2.68) | 4.79E-12 | 0.6215 |
| United States | 0.024 | 0.012 | 1671 | 1685 | 1.98 (1.59–2.37) | 5.82E-04 | 0.0532 | ||||
| Sweden | 0.031 | 0.006 | 113 | 177 | 5.78 (4.19–7.37) | 3.06E-02 | - | ||||
| Combined | 0.033 | 0.017 | 3179 | 6300 | 2.32 (2.11-2.53) | 3.00E-15 | 0.1992 | ||||
| rs7644486 | 3:57869963 | C | T | Discovery | 0.319 | 0.260 | 1395 | 4438 | 1.32 (1.23–1.41) | 5.34E-09 | 0.4966 |
| United States | 0.303 | 0.287 | 1677 | 1693 | 1.08 (0.98–1.19) | 1.44E-01 | 0.3867 | ||||
| Sweden | 0.292 | 0.297 | 113 | 177 | 0.98 (0.61–1.35) | 9.05E-01 | - | ||||
| Combined | 0.309 | 0.268 | 3185 | 6308 | 1.20 (1.13–1.27) | 1.83E-07 | 0.0370 | ||||
| rs11712066 | 3:151830309 | G | A | Discovery | 0.171 | 0.252 | 1395 | 4438 | 0.62 (0.52–0.73) | 3.73E-17 | 0.7899 |
| United States | 0.148 | 0.209 | 1671 | 1676 | 0.65 (0.53–0.78) | 8.29E-11 | 0.9453 | ||||
| Sweden | 0.161 | 0.231 | 112 | 175 | 0.62 (0.16–1.07) | 3.54E-02 | - | ||||
| Combined | 0.159 | 0.240 | 3178 | 6289 | 0.64 (0.55–0.72) | 2.57E-27 | 0.9840 | ||||
| rs573872 | 3:153472163 | G | T | Discovery | 0.280 | 0.225 | 1395 | 4438 | 1.33 (1.23–1.43) | 7.74E-09 | 0.2193 |
| United States | 0.241 | 0.203 | 1671 | 1684 | 1.24 (1.12–1.35) | 2.90E-04 | 0.0522 | ||||
| Sweden | 0.336 | 0.214 | 113 | 175 | 1.88 (1.49–2.26) | 1.42E-03 | - | ||||
| Combined | 0.261 | 0.219 | 3179 | 6297 | 1.31 (1.24–1.38) | 4.96E-13 | 0.0455 | ||||
| rs6556059 | 5:172645766 | T | C | Discovery | 0.452 | 0.355 | 1395 | 4438 | 1.50 (1.41–1.59) | 4.24E-19 | 0.5220 |
| United States | 0.426 | 0.343 | 1667 | 1680 | 1.42 (1.32–1.52) | 4.27E-12 | 0.9360 | ||||
| Sweden | 0.474 | 0.334 | 113 | 175 | 1.79 (1.44–2.14) | 1.10E-03 | - | ||||
| Combined | 0.439 | 0.351 | 3175 | 6293 | 1.48 (1.41–1.54) | 1.49E-31 | 0.6910 | ||||
| rs1933683 | 9:96712771 | G | C | Discovery | 0.131 | 0.094 | 1395 | 4438 | 1.50 (1.36–1.64) | 4.58E-09 | 0.8138 |
| United States | 0.139 | 0.120 | 1671 | 1685 | 1.22 (1.10–1.34) | 1.17E-03 | 0.5543 | ||||
| Sweden | 0.170 | 0.127 | 112 | 177 | 1.40 (0.93–1.87) | 1.58E-01 | - | ||||
| Combined | 0.136 | 0.102 | 3178 | 6300 | 1.34 (1.24–1.43) | 3.05E-09 | 0.1920 | ||||
| rs12721025 | 11:116706047 | A | G | Discovery | 0.087 | 0.058 | 1395 | 4438 | 1.58 (1.42–1.74) | 4.12E-08 | 0.8483 |
| United States | 0.087 | 0.069 | 1667 | 1671 | 1.27 (1.09–1.45) | 9.39E-03 | 0.0318 | ||||
| Sweden | 0.097 | 0.051 | 113 | 175 | 2.03 (1.37–2.69) | 3.56E-02 | - | ||||
| Combined | 0.087 | 0.061 | 3175 | 6284 | 1.45 (1.33–1.57) | 1.07E-09 | 0.0691 | ||||
SNP, dbSNP v146 variant ID; Position, hg19 human genome assembly; A1, effect allele; A2, alternative allele; Frequency, effect allele frequency; odds ratio [OR; 95% confidence interval (CI)], OR of the effect allele (95% CI); P, fixed-effects meta-analysis P-value; Q, P-value for Cochrane's Q statistic (measure of heterogeneity). All specimens are of European ancestry.