Table 1.
SNPs related to genes potentially involved in fibromyalgia’s pathogenesis.
| SNPs | Gene | Clinical relevance |
|---|---|---|
| 5-HTTLPR24 | SLC6A4 | Temporal mandibular joint disorderDepressionPsychological disorders |
| rs468028 | COMT | DepressionAnxietyDisability |
| rs104810129 | HTR2A | FIQ disability |
| rs631330,31 | HTR2A | Fibromyalgia onset |
| rs1112729232 | MYT1L | Cognitive disability |
| Intronic CNV32 | NRXN3 | Autism |
| rs8192619, rs412925633 | TAAR1 | Impaired dopamine availabilityEnhanced pain sensitivity |
| rs10799897, rs2842003, rs280505033 | RGS4 | Alteration in the descending inhibition of pain perception |
| rs6454674, rs1078602, rs1048517133 | CNR1 | MigraineIrritable bowel syndromePost-traumatic stress disorder |
| rs642544, rs17104711, rs2510177, rs1089583733 | GRIA4 | Central sensitization |
SNP: Single Nucleuotide Polymorphism; CNV: copy number variant.