Table 2.
Genes differentially methylated in FM women.
| Gene | Biological samples | Physiological function | Associations |
|---|---|---|---|
| BDNF 73 | Blood | Neuron Differentiation/nervous system development | Mood disordersAlzheimerParkinson Huntington’s disease |
| NAT15 73 | Blood | Histone acetyltransferaseChromatin compaction | Acetylation processFacilitation of transcription process |
| HDAC4 73 | Blood | Deacetylation of the core histonesMuscle maturation | Deacetylation’s processGene silencing |
| PRKCA 73 | Blood | Cell signaling pathways | Post-traumatic stress syndromeEmotional memory formationCancer |
| RTN1 73 | Blood | Secretion or membrane trafficking in neuroendocrine cells | Neurological diseases Cancer |
| PRKG1 73 | Blood | Regulation cardiovascular and neuronal functions Relax smooth muscle tonePrevent platelet aggregationModulate cell growth | Aortic aneurysmPhosphoglycerate kinase deficiency |
| SLC17A9 74 | Blood | Regulation neuronal differentiation | Neuronal plasticity |
| TFAP2A 74 | Blood | Survival functions of sympathetic progenitors and noradrenergic neurons | Neuronal circuits |
A general hypomethylated pattern in FM patients compared to healthy subjects seem to be revealed, considering the first studies on DNA methylation and FM.