TABLE 3.

Domain Calculations and Descriptions for CNS Vital Signs

Domain: Subtest	Test Description
NCI: Mean of 5 domain scores	Composite memory, psychomotor speed, reaction time, complex attention, and cognitive flexibility (see below).
Verbal memory: Verbal Memory Test	Participant was presented with 15 words and instructed to identify those words nested among 15 new words at the beginning of the test battery and once at the end.
Visual memory: Visual Memory Test	Participant was presented with 15 shapes and instructed to identify those shapes nested among 15 new shapes at the beginning of the test battery and once at the end.
Composite memorya
Verbal Memory Test	As described
Visual Memory Test	As described
Psychomotor speeda
Finger Tapping Test	Using the right or left index finger, the participant was instructed to press the space bar as many times as possible in 10 s.
Symbol Digit Coding	Participant was instructed to correctly type in numbers that were linked to a symbol from a key.
Reaction timea: Stroop Test	Participant was instructed to press the spacebar first when the font color matches the text using the words “blue,” “red,” “yellow,” and “green.” The test was then repeated where the participant pressed the spacebar when the font color did not match the text.
Complex attentiona
Continuous Performance Test	Participant was told to press the spacebar every time the letter “B” appeared on the screen.
Shifting Attention Test	Participant was instructed to press the shift key for the symbol of the side, which matched a condition specified at the top of the screen.
Stroop Test	As described
Cognitive flexibilitya
Shifting Attention Test	As described
Stroop Test	As described
Processing speed: Symbol Digit Coding	As described
Executive functioning: Shifting Attention	As described
Simple attention: Continuous Performance Test	As described
Motor speed: Finger Tapping Test	As described

^aThese domain scores are averaged to derive the NCI (Neurocognitive Index) which was used for our analyses.