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Working mechanism of the drug–drug interaction with an ASA: MKIs are arranged according to the clinical relevance and magnitude of the interaction in a descending order, with the most relevant interactions on top of the list. A PPI increases stomach pH after intake and thereby decreases absorption of MKIs and therefore bioavailability of MKIs.
ASA, acid-suppressive agent; DDI, drug–drug interaction; MKI, multikinase.
