Table 2.
MYC‐regulated lncRNAs with a function related to important hallmarks of cancer
| Proven target gene(s) | Cellular processesa | |
|---|---|---|
| MYC‐induced | ||
| BCYRN1 | ↑ MMP2/9/13, VEGF | Angiogenesis, metastasis |
| CASC11 | ↑ HNRNPK | Cell cycle progression |
| ↓ WIF1 | Metastasis | |
| CCAT1‐S | ↑ BIRC7 | Apoptosis |
| ↓ CDKN1A, let‐7a/b/c/e‐5p, miR‐148a‐3p | Cell cycle progression, metastasis | |
| CCAT6 | ↓ CDKN2B | Cell cycle progression |
| CONCR | ↑ DDX11 | Cell cycle progression |
| DANCR | ↓ CDKN1A, miR‐33b‐5p | Cell cycle progression |
| H19 | ↓ CDH1, let‐7a/b‐5p, miR‐29a‐3p, miR‐106a‐5p, miR‐200a‐c‐3p | Cell cycle progression, metabolism, angiogenesis, metastasis |
| HOTAIR | ↓ CDKN1A, WIF1, miR‐34a‐5p | Cell cycle progression, metastasis, |
| LAST | ↑ CCND1 | Cell cycle progression |
| Linc00176 | ↓ miR‐9‐5p, miR‐185‐5p | Cell cycle progression |
| LncRNA‐MIF | ↓ miR‐586‐5p | Metabolism |
| MINCR | ↓ miR‐26a‐5p | Cell cycle progression, apoptosis, metastasis |
| MYCLo‐1 | ↓ CDKN1A | Cell cycle progression |
| MYU | ↑ CDK6 | Cell cycle progression |
| SINGH12 | ↑ MMP13 | Metastasis |
| MYC‐repressed | ||
| IDH1‐AS1 | ↑ IDH1 | Metabolism |
| MYCLo‐4 | ↑ GADD45A | Cell cycle progression |
| MYCLo‐5 | Unknown | Cell cycle progression |
| MYCLo‐6 | ↑ GADD45A | Cell cycle progression |
↑ indicates induced/stabilized/activated by the lncRNA, and ↓ indicates being repressed by the lncRNA. aNot all proven target genes mentioned in column two are involved in the cellular processes mentioned here.