Fig. 2.
The effects of E7016 on tumor cell radiosensitivity. Cells were seeded as a single-cell suspension and with a specified number of cells. After allowing cells time to attach (16 h), E7016 or the vehicle control was added at specified concentrations and the plates were irradiated 6 h later. Ten to twelve days after seeding, survival curves were generated after normalizing for the cytotoxicity generated by E7016 alone. A, U251 (3 μmol/L). B, MiaPaCa (3 μmol/L). C, DU145 (5 μmol/L).
Data presented are the mean ± SE from at least three independent experiments. ● = irradiation alone; ○ = irradiation plus E7016; DEF, dose enhancement factor.