Fig. 6.

Influence of E7016 on radiation-induced tumor growth delay. Mice were implanted with 1 × 10⁶ U251 cells on the lateral aspect of the rear leg. Tumors were randomized at 172 mm³ into four groups and treated with either vehicle control, E7016 alone (40 mg/kg by oral gavage), temozolomide (3 mg/kg orally) followed by radiotherapy, or E7016/temozolomide/4Gy. Tumors were measured three times per week and followed until they reached at least 1,000 mm³. Volumes were calculated using the formula (L × W × W)/2. ● = vehicle alone; ○ = E7016 alone; ▼ = temozolomide/radiotherapy, ◇ = E7016/temozolomide/radiotherapy.