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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: J Cell Physiol. 2018 Sep 10;234(4):4874–4887. doi: 10.1002/jcp.27276

Figure 5. Neratinib down-regulates the expression of chaperone proteins.

Figure 5.

A. HCT116, SW480 and HT29 cells were treated with vehicle control or with neratinib (50 nM). Cells were fixed in place after 6h and immuno-staining against the chaperones COOH-termini performed to determine the total expression of GRP78 and HSP90. (n = 3, * p < 0.05 less than vehicle control value +/− SEM). B. HCT116 colon cancer cells were treated with vehicle control or with [regorafenib (0.5 μM) + sildenafil (2.0 μM)] for 6h. Cells were fixed in place and immunostaining performed to determine the expression of the indicated growth factor receptors. (n = 3, * p < 0.05 less than vehicle control value +/− SEM).