Table 2.
Baseline demographics; clinical characteristics; cognitive, biochemical, and imaging parameters in mutation carriers with high (i.e., ≥150 min/week) or low (i.e., <150 min/week) physical activity
| Baseline characteristics | High-active mutation carriers (n = 156) | Low-active mutation carriers (n = 68) | P value |
|---|---|---|---|
| Age (years) | 37.3 (10.2) | 41.1 (8.9) | .0084 |
| Estimated years till symptom onset | −9.6 (8.4) | − 5.3 (8.2) | .0012 |
| Gender (females, %) | 84 (54%) | 42 (62%) | .272 |
| Education (years) | 14.1 (3.1) | 13.8 (3.3) | .496 |
| Geriatric Depression Scale | 2.1 (2.6) | 2.5 (2.6) | .252 |
| MMSE | 28.2 (2.5) | 25.1 (6.4) | <.0001 |
| CDR global score | 0.2 (0.3) | 0.4 (0.4) | .0002 |
| CDR-SOB | 0.7 (1.4) | 2.0 (3.2) | <.0001 |
| Physical activity (min/week) | 425.5 (159.2) | 58.9 (52.4) | <.0001 |
| Global PIB-uptake | 1.39 (0.3) | 1.52 (0.5) | .0539 |
| CSF amyloid-β1–42 (pg/mL) | 581.5 (305.2) | 470.6 (259.2) | .0178 |
| CSF t-tau (pg/mL) | 103.7 (67.1) | 144.3 (106.9) | .0019 |
| CSF p-tau181 (pg/mL) | 60.8 (35.6) | 72.2 (42.0) | .0296 |
| t-tau/amyloid-β1–42 ratio | 0.25 (0.2) | 0.43 (0.4) | .0002 |
| p-tau/amyloid-β1–42 ratio | 0.15 (0.1) | 0.21 (0.2) | .0146 |
Abbreviations: CDR, Clinical Dementia Rating scale; Global t-tau, total tau; MMSE, Mini Mental State Examination; PIB-uptake, global cerebral amyloid-b burden as measured by 11C-Pittsburgh Compound-B PET; p-tau, phosphorylated tau; SOB, Sum of Boxes.
NOTE. Data are given as mean (SD) or number (%). Significant differences are in bold.
NOTE. Mutation carriers with high physical activity reported 150 or more minutes of exercise per week, and mutation carriers with low physical activity reported less than 150 minutes per week of exercise.