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. 2019 Jan 7;25:1. doi: 10.1186/s10020-018-0068-8

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Hypothesized model. Schematic overview of the colon before and after sympathetic denervation. In Rag1^−/− mice after sympathectomy, there are more immature monocytes (‘Mo’, in red) compared to mature macrophages (‘Mϕ’, in blue), there is goblet cell depletion and levels of pro-inflammatory cytokines are higher compared to the sham group