. 2018 Oct 1;74(1):96–107. doi: 10.1093/jac/dky386

Table 5.

Relative increase in activity under different approximated physiological conditions

		Fold decrease in MIC compared with CAMHB^a
		LS-sarcotoxin				LS-stomoxyn
Test strain^b	Phenotype	N	C	S	S + N	N	C	S	S + N
E. coli	S	1	1	16	128	1	1	64	256
E. coli	MEM^R	1	1	32	128	1	0.5	128	256
K. pneumoniae	S	1	1	32	32	0.5	0.5	128	256
K. pneumoniae	MEM^R	0.5	1	8	32	0.5	0.5	64	256
A. baumannii	S	1	1	16	128	0.5	0.5	32	256
A. baumannii	MEM^R	1	1	16	128	1	0.5	64	256
P. aeruginosa	S	ND	ND	0.5	0.25	0.5	0.5	4	4
P. aeruginosa	MEM^R	ND	ND	0.25	0.25	1	0.5	0.5	0.5
E. coli	CST^R	ND	ND	16	32	ND	ND	32	64
K. pneumoniae	CST^R	ND	ND	8	16	ND	ND	16	64

ND, not determined.

MICs were determined in CAMHB, CAMHB adjusted to 150 mM NaCl (N) or 1.25 mM CaCl₂ (C), CAMHB supplemented with 10% human serum (S) and CAMHB supplemented with 10% human serum and adjusted to 150 mM NaCl (S + N). Fold changes in MIC values were calculated with respect to the MIC values obtained in CAMHB.

MIC values were determined for the colistin/meropenem-susceptible (S) strains E. coli ATCC 25922, K. pneumoniae DSM 30104, A. baumannii ATCC 19606, P. aeruginosa ATCC 27853, the meropenem-resistant (MEM^R) strains E. coli RKI 131/03, K. pneumoniae RKI 93/10, A. baumannii RKI 19/09, P. aeruginosa RKI 93/12 and the colistin-resistant (CST^R) strains E. coli RKI 6A-6 and K. pneumoniae RKI 19/16.