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. 2019 Jan 7;20:2. doi: 10.1186/s12865-018-0279-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Effects of the NSG-cmah^−/− background on human immune cells IGH genes repertoires. a Histograms of IgH CDR3 length (nucleotides) in spleen of NSG-cmah^−/− and b NSG mice. c NSG-cmah^−/− background was associated with a lower frequency of clonal B-cell expansion in spleen. d After transition from bone marrow to spleen, clonal B-cell expansion increased in NSG- cmah^−/− mice. Statistical analysis of CDR3 length was performed immunoSEQ Analyzer (https://www.adaptivebiotech.com/). P < 0.05 was considered a statistically significant. Five animals per strain were used. Individual CDR3 length in spleen (mature compartment) and bone marrow (developmental compartment) are shown on Additional file 2: Figure S2.