Table 1.
List of consensus motifs corresponding to known transcription factors significantly enriched in the set of differential histone-modified regions that are associated with P. falciparum infection
| Histone | Motif | P values | % Targets/background | TF BS predicted (score) | FlyBase record | Function |
|---|---|---|---|---|---|---|
| H3K9ac | CGTTCCCYWTTT | 1E−23 | 18.40/1.06 | kni/dmmpmm/fly (0.64) | http://flybase.org/reports/FBgn0001320 | Development, gene expression |
| AACKATTT | 1E−23 | 18.40/1.02 | br-Z2/dmmpmm/fly (0.727) | http://flybase.org/reports/FBgn0283451 | Development, gene expression, reproduction, response to stimulus | |
| GTGCGTRA | 1E−23 | 18.40/1.20 | z/dmmpmm/fly (0.71) | http://flybase.org/reports/FBgn0000629.htm | Gene expression, nucleus | |
| GCGATAGA | 1E−21 | 20.80/1.68 | Dref/dmmpmm/fly (0.75) | http://flybase.org/reports/FBgn0015664.htm | Development, gene expression, metabolism | |
| MCCGAGCN | 1E−20 | 16.00/0.64 | Deaf1/dmmpmm/fly (0.70) | http://beta.flybase.org/reports/FBgn0013799.htm | Immune system, development, gene expression | |
| TAATCCRY | 1E−19 | 16.00/0.93 | Gsc/dmmpmm/fly (0.88) | http://flybase.org/reports/FBgn0010323 | Gene expression, other molecular function | |
| CATCCTGGCG | 1E−17 | 24.00/3.41 | brk/dmmpmm/fly (0.679) | http://flybase.org/reports/FBgn0024250 | Development, gene expression, signaling, response to stimulus | |
| TCCTTCGA | 1E−15 | 17.60/2.23 | ttk/dmmpmm/fly (0.71) | http://flybase.org/reports/FBgn0003870 | Development, reproduction, response to stimulus, cell organization–biogenesis | |
| CTTGTTCTTC | 1E−15 | 13.60/0.58 | pan/dmmpmm/fly (0.63) | http://flybase.org/reports/FBgn0085432 | Signaling, gene expression, immune system | |
| TTCGTAATAC | 1E−15 | 13.60/1.46 | gt/dmmpmm/fly (0.66) | http://flybase.org/reports/FBgn0001150 | Development, gene expression, transcription factor | |
| GCTTGCTY | 1E−14 | 16.80/2.34 | grh/dmmpmm/fly (0.72) | http://flybase.org/reports/FBgn0259211 | Development, biogenesis | |
| AGCTTTAA | 1E−12 | 15.70/2.29 | zen/dmmpmm/fly (0.70) | http://flybase.org/reports/FBgn0004053 | Development, gene expression, transcription factor | |
| H3K27ac | GGCTCGTC | 1E−29 | 11.74/0.43 | h/dmmpmm/fly(0.676) | http://flybase.org/reports/FBgn0001168.htm | Development, gene expression, DNA binding |
| ATTTTTCCCC | 1E−21 | 9.39/0.65 | dl/dmmpmm/fly (0.69) | http://flybase.org/reports/FBgn0260632.htm | Immune system, development, gene expression | |
| AGAACAGTAA | 1E−21 | 9.39/0.40 | ara/dmmpmm/fly (0.67) | http://flybase.org/reports/FBgn0015904 | Development, gene expression | |
| GTGCAGCTCG | 1E−21 | 9.39/0.65 | sna/dmmpmm/fly (0.65) | http://flybase.org/reports/FBgn0003448 | Development, gene expression, DNA binding | |
| CAAAAACGCAAC | 1E−21 | 9.39/0.67 | hb/dmmpmm/fly (0.744) | http://flybase.org/reports/FBgn0001180 | Development, gene expression, transcription factor | |
| CTATGTTT | 1E−16 | 9.86/0.84 | pan/dmmpmm/fly (0.80) | http://flybase.org/reports/FBgn0085432 | Signaling, gene expression, immune system | |
| TCGATCGTCG | 1E−15 | 7.51/0.00 | Dref/dmmpmm/fly (0.60) | http://flybase.org/reports/FBgn0015664.html | Development, gene expression, DNA binding, transcription factor, cell cycle, DNA metabolism | |
| ATWTCTGC | 1E−13 | 8.45/1.00 | grh/dmmpmm/fly (0.714) | http://flybase.org/reports/FBgn0259211 | Development, biogenesis | |
| CTTCADTGCGGA | 1E−13 | 6.57/0.66 | slbo/dmmpmm/fly (0.661) | http://flybase.org/reports/FBgn0005638 | Development, gene expression, reproduction | |
| CACGAAGT | 1E− 12 | 12.68/2.32 | Eip74EF/dmmpmm/fly (0.772) | http://flybase.org/reports/FBgn0000567 | Development, reproduction | |
| H3K4me3 | ARTTTTGTGT | 1E−30 | 5.16/0.27 | br-Z3/dmmpmm/fly (0.70) | http://flybase.org/reports/FBgn0283451 | Development, gene expression, reproduction, response to stimuli |
| TTTGATTCGTAA | 1E−30 | 5.16/0.28 | ara/dmmpmm/fly (0.67) | http://flybase.org/reports/FBgn0015904 | Development, gene expression | |
| CTTCTTGCCCGA | 1E−23 | 5.34/0.49 | Eip74EF/dmmpmm/fly (0.62) | http://flybase.org/reports/FBgn0000567 | Development, gene expression, reproduction | |
| CGAARAAGAR | 1E−18 | 5.34/0.56 | pan/dmmpmm/fly (0.70) | http://flybase.org/reports/FBgn0085432 | Development, gene expression, response to stimulus, signaling, immune system | |
| TCCTCGTCGTTG | 1E−16 | 7.55/1.60 | Aef1/dmmpmm/fly (0.56) | http://flybase.org/reports/FBgn0005694.htm | Other molecular function | |
| H3K9me3 | AGCGCCTGGT | 1E−26 | 8.82/0.61 | brk/dmmpmm/fly (0.688) | http://flybase.org/reports/FBgn0024250 | Development, gene expression, response to stimulus, signaling |
| YCTGTGACCG | 1E−24 | 8.46/0.59 | Hth/dmmpmm/fly (0.72) | http://flybase.org/reports/FBgn0001235 | Development, gene expression, DNA binding, transport/localization, transcription facto | |
| TCYKGWAKCKGA | 1E−24 | 8.46/0.58 | Pnt/dmmpmm/fly (0.60) | http://flybase.org/reports/FBgn0003118 | Development, gene expression, response to stimulus, signaling, immune system, cell cycle/proliferation, DNA binding | |
| ACTCCAGATA | 1E−21 | 7.72/0.57 | z/dmmpmm/fly (0.61) | http://flybase.org/reports/FBgn0000629.html | Development, gene expression, protein metabolism, cell organization/biogenesis, enzyme | |
| CTAYTTAT | 1E−21 | 7.72/0.18 | bin/dmmpmm/fly (0.829) | http://flybase.org/reports/FBgn0045759 | Development, gene expression, transcription factor | |
| ATCTCGGG | 1E−21 | 7.72/0.53 | Deaf1/dmmpmm/fly (0.68) | http://beta.flybase.org/reports/FBgn0013799.html | Development, gene expression, immune system, response to stimulus, transcription factor | |
| CATTCGAC | 1E−21 | 9.56/0.81 | sd/dmmpmm/fly (0.70) | http://flybase.org/reports/FBgn0003345 | Development, gene expression, other molecular function, DNA binding, cell cycle/proliferation | |
| RCGAAATTTTTG | 1E−20 | 7.35/0.22 | cad/dmmpmm/fly (0.76) | http://flybase.org/reports/FBgn0000251 | Development, gene expression, response to stimulus, transcription factor, DNA binding, immune system | |
| TTAGACGA | 1E−20 | 7.35/0.40 | exd/dmmpmm/fly (0.67) | http://flybase.org/reports/FBgn0000611 | Development, gene expression, other molecular function, DNA binding, transcription factor |