Table 5.

Hazard ratio’s for macrolides during admission

	Working diagnosis of CAP N = 2107; 146 n/w cardiac events		Radiologically proven CAP N = 1604; 115 n/w cardiac events
Outcome antibiotic	Crude HR (CI)	Adjusted HR (CI)	Crude HR (CI)	Adjusted HR (CI)
n/w Cardiac event
azithromycin	0.70 (0.39;1.26)	0.76 (0.42;1.35)	0.59 (0.29;1.18)	0.66 (0.33;1.32)
clarithromycin	0.84 (0.51;1.38)	1.03 (0.62;1.70)	0.88 (0.52;1.51)	1.09 (0.63;1.88)
erythromycin	1.60 (1.09;2.36)	1.82 (1.23;2.68)	1.53 (1.00;2.35)	1.67 (1.09;2.57)
n/w Heart failure
azithromycin	0.73 (0.38;1.41)	0.78 (0.40;1.52)	0.61 (0.28;1.35)	0.69 (0.32;1.53)
clarithromycin	0.93 (0.53;1.64)	1.17 (0.66;2.08)	0.92 (0.49;1.70)	1.20 (0.64;2.24)
erythromycin	1.89 (1.22;2.91)	2.11 (1.36;3.26)	1.67 (1.03;2.71)	1.77 (1.09;2.87)
n/w Arrhythmia
azithromycin	1.00 (0.42;2.39)	1.03 (0.43;2.47)	0.77 (0.27;2.21)	0.85 (0.30;2.45)
clarithromycin	0.76 (0.31;1.84)	0.87 (0.36;2.12)	0.88 (0.36;2.17)	1.02 (0.41;2.53)
erythromycin	1.25 (0.62;2.49)	1.28 (0.64;2.57)	1.30 (0.62;2.72)	1.32 (0.63;2.78)

n/w = new or worsening

Hazard ratio’s (HR’s) with 95% confidence intervals (CIs) from Cox PH models for time-dependent exposure to different macrolides during admission on cardiac events. Adjusted HR’s are adjusted for confounders mentioned in Methods