Table 7.
Sub-distribution hazard ratio’s for macrolides during admission
| Working diagnosis of CAP N = 2107; 146 n/w cardiac events |
Radiologically proven CAP N = 1604; 115 n/w cardiac events |
|||
|---|---|---|---|---|
| Outcome antibiotic |
Crude HR (CI) | Adjusted HR (CI) | Crude HR (CI) | Adjusted HR (CI) |
| n/w Cardiac event | ||||
| azithromycin | 0.86 (0.48;1.53) | 0.93 (0.52;1.67) | 0.73 (0.37;1.46) | 0.84 (0.42;1.68) |
| clarithromycin | 1.11 (0.68;1.83) | 1.34 (0.81;2.22) | 1.19 (0.70;2.04) | 1.47 (0.85;2.52) |
| erythromycin | 1.73 (1.17;2.55) | 1.99 (1.35;2.94) | 1.66 (1.08;2.56) | 1.87 (1.21;2.88) |
| n/w Heart failure | ||||
| azithromycin | 0.90 (0.46;1.74) | 1.00 (0.51;1.94) | 0.76 (0.35;1.67) | 0.91 (0.41;2.00) |
| clarithromycin | 1.25 (0.71;2.20) | 1.57 (0.89;2.79) | 1.26 (0.68;2.33) | 1.67 (0.89;3.12) |
| erythromycin | 2.06 (1.33;3.18) | 2.35 (1.52;3.65) | 1.84 (1.13;3.00) | 2.01 (1.23;3.28) |
| n/w Arrhythmia | ||||
| azithromycin | 1.22 (0.51;2.91) | 1.28 (0.54;3.07) | 0.96 (0.33;2.73) | 1.09 (0.38;3.14) |
| clarithromycin | 1.02 (0.42;2.47) | 1.18 (0.48;2.85) | 1.21 (0.49;2.98) | 1.43 (0.57;3.55) |
| erythromycin | 1.37 (0.69;2.74) | 1.44 (0.72;2.88) | 1.44 (0.68;3.02) | 1.49 (0.71;3.15) |
n/w = new or worsening
Sub-distribution hazard ratio’s (SDHR’s) with 95% confidence intervals (CIs) from Cox PH models for time-dependent exposure to different macrolides during admission on cardiac events. Adjusted SDHR’s are adjusted for confounders mentioned in Methods