Table 8.

Sub-distribution hazard ratio’s for fluoroquinolones during admission

	Working diagnosis of CAP N = 2107; 146 n/w cardiac events		Radiologically proven CAP N = 1604; 115 n/w cardiac events
Outcome antibiotic	Crude HR (CI)	Adjusted HR (CI)	Crude HR (CI)	Adjusted HR (CI)
n/w cardiac event
ciprofloxacin	1.09 (0.61;1.94)	0.95 (0.53;1.70)	1.18 (0.64;2.17)	1.00 (0.54;1.85)
levofloxacin	0.49 (0.23;1.07)	0.52 (0.24;1.13)	0.40 (0.15;1.11)	0.43 (0.15;1.18)
moxifloxacin	0.68 (0.44;1.06)	0.68 (0.43;1.06)	0.65 (0.40;1.07)	0.66 (0.40;1.10)
n/w Heart failure
ciprofloxacin	1.05 (0.52;2.10)	0.91 (0.46;1.84)	1.06 (0.51;2.24)	0.89 (0.42;1.87)
levofloxacin	0.31 (0.10;0.98)	0.33 (0.10;1.05)	0.14 (0.02;1.02)	0.15 (0.02;1.08)
moxifloxacin	0.58 (0.33;1.01)	0.60 (0.35;1.06)	0.53 (0.29;1.00)	0.57 (0.30;1.06)
n/w Arrhythmia
ciprofloxacin	1.19 (0.46;3.04)	1.04 (0.40;2.66)	1.08 (0.38;3.10)	0.93 (0.32;2.66)
levofloxacin	0.62 (0.19;2.05)	0.61 (0.19;2.02)	0.88 (0.26;2.95)	0.87 (0.26;2.91)
moxifloxacin	0.81 (0.40;1.65)	0.82 (0.40;1.65)	0.86 (0.40;1.83)	0.89 (0.42;1.89)

n/w = new or worsening

Sub-distribution hazard ratio’s (SDHR’s) with 95% confidence intervals (CIs) from Cox PH models for time-dependent exposure to different fluoroquinolones during admission on cardiac events. Adjusted SDHR’s are adjusted for confounders mentioned in Methods