Table 8.
Joint analysis of the prognostic value of combination of KIF15, KIF20A, KIF23, KIF2C, and KIF4A expression of BC.
| Group | Patients | MST (days) | Crude p | Crude HR | Adjusted p | Adjusted HR(95% CI) * |
|---|---|---|---|---|---|---|
| 1 | 432 | 3736 | 0.367 | 1 | 0.065 | 1 |
| 2 | 192 | 3941 | 0.185 | 1.354 (0.865–2.121) | 0.16 | 1.419 (0.87–2.313) |
| 3 | 431 | 6593 | 0.291 | 1.219 (0.844–1.759) | 0.021 | 1.578 (1.073–2.322) |
| 4 | 444 | 3669 | 0.439 | 1 | 0.049 | 1 |
| 5 | 168 | 4456 | 0.229 | 1.328 (0.836–2.11) | 0.223 | 1.363 (0.828–2.245) |
| 6 | 443 | 3959 | 0.356 | 1.184 (0.827–1.695) | 0.014 | 1.615 (1.1–2.372) |
| 7 | 428 | 3736 | 0.398 | 1 | 0.008 | 1 |
| 8 | 200 | 6456 | 0.279 | 1.296 (0.811–2.071) | 0.021 | 1.825 (1.097–3.037) |
| 9 | 427 | 3959 | 0.23 | 1.244 (0.871–1.778) | 0.003 | 1.776 (1.211–2.604) |
| 10 | 436 | 3669 | 0.237 | 1 | 0.013 | 1 |
| 11 | 184 | 6456 | 0.396 | 1.223 (0.768–1.946) | 0.196 | 1.39 (0.843–2.29) |
| 12 | 435 | 3873 | 0.09 | 1.369 (0.952–1.967) | 0.003 | 1.787 (1.215–2.63) |
| 13 | 450 | 3736 | 0.292 | 1 | 0.038 | 1 |
| 14 | 156 | 3461 | 0.265 | 1.317 (0.812–2.137) | 0.116 | 1.508 (0.904–2.517) |
| 15 | 449 | 3959 | 0.14 | 1.308 (0.916–1.87) | 0.012 | 1.625 (1.112–2.374) |
| 16 | 441 | 3736 | 0.221 | 1 | 0.008 | 1 |
| 17 | 174 | 4456 | 0.546 | 1.169 (0.704–1.94) | 0.652 | 1.133 (0.659–1.949) |
| 18 | 440 | 3959 | 0.083 | 1.366 (0.96–1.944) | 0.003 | 1.76 (1.21–2.56) |
| 19 | 454 | 3736 | 0.051 | 1 | 0.011 | 1 |
| 20 | 148 | 6593 | 0.772 | 0.919 (0.518–1.631) | 0.735 | 1.114 (0.598–2.074) |
| 21 | 453 | 3941 | 0.032 | 1.463 (1.034–2.07) | 0.004 | 1.715 (1.188–2.475) |
| 22 | 445 | 3736 | 0.207 | 1 | 0.006 | 1 |
| 23 | 166 | 3941 | 0.197 | 1.379 (0.846–2.249) | 0.394 | 1.258 (0.742–2.131) |
| 24 | 444 | 3959 | 0.101 | 1.344 (0.944–1.914) | 0.002 | 1.844 (1.262–2.696) |
| 25 | 453 | 3736 | 0.070 | 1 | 0.004 | 1 |
| 26 | 150 | NUM | 0.805 | 0.93 (0.525–1.648) | 0.932 | 1.026 (0.573–1.837) |
| 27 | 452 | 3941 | 0.040 | 1.436 (1.017–2.027) | 0.002 | 1.787 (1.236–2.585) |
| 28 | 457 | 3736 | 0.033 | 1 | 0.001 | 1 |
| 29 | 142 | 4456 | 0.751 | 0.909 (0.505–1.636) | 0.457 | 0.785 (0.414–1.486) |
| 30 | 456 | 3873 | 0.020 | 1.503 (1.066–2.12) | 0.001 | 1.93 (1.34–2.78) |
| a | 402 | 3736 | 0.343 | 1 | 0.042 | 1 |
| b | 258 | 3941 | 0.157 | 1.354 (0.89–2.059) | 0.097 | 1.466 (0.933–2.302) |
| c | 395 | 3959 | 0.298 | 1.225 (0.836–1.794) | 0.013 | 1.674 (1.113–2.516) |
| d | 390 | 3736 | 0.37 | 1 | 0.04 | 1 |
| e | 283 | 3941 | 0.232 | 1.296 (0.847–1.983) | 0.129 | 1.426 (0.902–2.254) |
| f | 382 | 3959 | 0.211 | 1.274 (0.872–1.861) | 0.011 | 1.675 (1.123–2.497) |
| g | 399 | 3736 | 0.335 | 1 | 0.028 | 1 |
| h | 262 | 4456 | 0.45 | 1.181 (0.767–1.818) | 0.225 | 1.335 (0.837–2.131) |
| i | 394 | 3959 | 0.139 | 1.328 (0.912–1.934) | 0.008 | 1.713 (1.152–2.548) |
| j | 399 | 3669 | 0.34 | 1 | 0.018 | 1 |
| k | 267 | 4456 | 0.168 | 1.348 (0.882–2.06) | 0.088 | 1.487 (0.942–2.346) |
| l | 389 | 3959 | 0.262 | 1.24 (0.851–1.805) | 0.005 | 1.787 (1.193–2.675) |
| m | 403 | 3669 | 0.44 | 1 | 0.019 | 1 |
| n | 251 | 6456 | 0.519 | 1.154 (0.747–1.782) | 0.316 | 1.267 (0.798–2.011) |
| o | 401 | 3873 | 0.2 | 1.275 (0.879–1.849) | 0.006 | 1.763 (1.181–2.631) |
| A | 398 | 3669 | 0.334 | 1 | 0.018 | 1 |
| B | 263 | 6456 | 0.558 | 1.14 (0.735–1.767) | 0.315 | 1.273 (0.795–2.04) |
| C | 394 | 3959 | 0.141 | 1.321 (0.912–1.913) | 0.005 | 1.749 (1.18–2.593) |
| D | 411 | 3736 | 0.424 | 1 | 0.026 | 1 |
| E | 248 | 3941 | 0.312 | 1.252 (0.809–1.937) | 0.316 | 1.269 (0.797–2.023) |
| F | 396 | 6456 | 0.225 | 1.258 (0.869–1.821) | 0.007 | 1.721 (1.158–2.559) |
| G | 419 | 3736 | 0.2 | 1 | 0.023 | 1 |
| H | 227 | 6593 | 0.885 | 1.035 (0.649–1.651) | 0.46 | 1.204 (0.735–1.973) |
| I | 409 | 3941 | 0.096 | 1.358 (0.947–1.949) | 0.007 | 1.691 (1.151–2.484) |
| J | 414 | 3736 | 0.081 | 1 | 0.002 | 1 |
| K | 232 | 4456 | 0.964 | 0.989 (0.613–1.597) | 0.97 | 0.99 (0.591–1.658) |
| L | 409 | 3873 | 0.046 | 1.44 (1.006–2.061) | 0.002 | 1.823 (1.248–2.664) |
| M | 419 | 3736 | 0.218 | 1 | 0.002 | 1 |
| N | 229 | 4456 | 0.891 | 1.033 (0.646–1.653) | 0.965 | 0.989 (0.6–1.629) |
| O | 407 | 3959 | 0.103 | 1.346 (0.942–1.925) | 0.002 | 1.865 (1.268–2.742) |
| I | 375 | 3736 | 0.391 | 1 | 0.044 | 1 |
| II | 324 | 3941 | 0.179 | 1.324 (0.879–1.995) | 0.103 | 1.44 (0.929–2.231) |
| III | 356 | 3959 | 0.353 | 1.203 (0.815–1.777) | 0.013 | 1.693 (1.115–2.569) |
| IV | 381 | 3736 | 0.477 | 1 | 0.038 | 1 |
| V | 304 | 4456 | 0.338 | 1.224 (0.81–1.852) | 0.189 | 1.347 (0.864–2.099) |
| VI | 370 | 3959 | 0.254 | 1.252 (0.851–1.843) | 0.01 | 1.715 (1.135–2.593) |
| VII | 375 | 3736 | 0.381 | 1 | 0.037 | 1 |
| VIII | 315 | 4456 | 0.376 | 1.208 (0.795–1.837) | 0.186 | 1.355 (0.864–2.124) |
| IX | 365 | 3959 | 0.169 | 1.309 (0.892–1.921) | 0.01 | 1.701 (1.135–2.55) |
| X | 381 | 3669 | 0.544 | 1 | 0.026 | 1 |
| XI | 306 | 4456 | 0.441 | 1.178 (0.776–1.789) | 0.257 | 1.294 (0.829–2.02) |
| XII | 368 | 3959 | 0.285 | 1.231 (0.841–1.801) | 0.007 | 1.752 (1.163–2.638) |
| XIII | 394 | 3736 | 0.41 | 1 | 0.015 | 1 |
| XIV | 287 | 3941 | 0.553 | 1.138 (0.742–1.745) | 0.479 | 1.179 (0.747–1.859) |
| XV | 374 | 3959 | 0.182 | 1.29 (0.887–1.876) | 0.006 | 1.768 (1.182–2.645) |
| ➀ | 364 | 3736 | 0.455 | 1 | 0.045 | 1 |
| ➁ | 348 | 3941 | 0.24 | 1.275 (0.85–1.912) | 0.128 | 1.4 (0.908–2.158) |
| ➂ | 343 | 3959 | 0.316 | 1.224 (0.824–1.816) | 0.013 | 1.708 (1.119–2.606) |
*
Adjusted for age (stratified by 65 years) and tumor stage. KIF – kinesin; OS – overall survival; MST – median survival time; HR – hazard ratio; CI: confidence interval.