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. Author manuscript; available in PMC: 2019 Jan 7.
Published in final edited form as: Curr Opin Struct Biol. 2018 Jul 19;53:88–99. doi: 10.1016/j.sbi.2018.06.004

Figure 2.

Figure 2

Examples of methyl-Arg-Gua recognition and 5caC recognition. (a) MBD domain of MeCP2. PDB codes are given, DNA recognition sequences are shown with M = 5mC, and key interactions of each DNA strand are shown above and below the recognition sequence. (b) Kaiso (ZF), (c) Zfp57 (ZF), (d) Klf4 (ZF), (e) Egr1 (ZF) and (f) WT1 (ZF). (g) Effects of binding of DNA with 5caC against Egr1 and WT1. (h) WT1 (Q369) recognition of DNA with 5caC. (i) The p53 proteins recognize TpG, which can be replaced by 5mCpG. (j) Klf4 mutant (D446) interacts with unmodified cytosine. (k) In CTCF (ZF), D451 and E362 recognize, respectively, unmodified cytosine at position 2 and 5mC at position 12. (l) Effects of methylation at specific sites on binding by CTCF. (m) MAX (bHLH) recognition of 5caC. (n) Pol II recognition of 5caC. (o) Tet3 CXXC domain recognition of 5caC.