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. 2015 May 1;92(5):127, 1-12. doi: 10.1095/biolreprod.115.128181

Fig. 4.

Fig. 4

Comparison of 24 h cumulative death rate in offspring from Gsk3a−/−bf/f, oGsk3a+/+b−/−, oGsk3a−/−b−/−, and breeding colony dams. Loss of oocyte GSK3A (Gsk3a−/−bf/f, n = 9 litters) or GSK3B (oGsk3a+/+b−/−, n = 10 litters) in dams did not increase offspring 24 h cumulative death rate in comparison to each other, nor to litters from the mouse breeding colony (n = 29 litters). However, concomitant loss of oocyte GSK3A and GSK3B (oGsk3a−/−b−/−, n = 13 litters) in dams significantly increased offspring 24 h cumulative death rate in comparison to litters from the mouse breeding colony, Gsk3a−/−bf/f, and oGsk3a+/+b−/− dams (P < 0.01). Values represent means ± SEM.