Fig. 5.

Histology analysis determined that offspring derived from the mouse breeding colony had normal hearts (A), kidneys (B, C), liver (D, E), lungs (F), and brains (G). However, animals derived from oocytes lacking both isoforms of GSK3 (oGsk3a^−/−b^−/− offspring) presented with great vessel and atrial dilation (H), ischemic nephrosis (I, J), severe liver congestion (K, L), and lung atelectasis (M); however, the brain had a normal appearance (N). Original magnification ×25 (A, H), ×100 (B, D, F, G, I, K, M, N), or ×400 (C, E, J, L).