TABLE 2.
Current IRPs for NAT assays (viral markers)
| Panel | Standard (code no.) | Materiala | Year of establishment | Reference |
|---|---|---|---|---|
| HBV genotypes (15 members) | First IRP (5086/08) | Viremic plasma diluted in pooled human plasma; HBV genotypes A1 (n = 2), A2, B2 (n = 2), B4, C2 (n = 3), D1 (n = 2), D3, E, F2, and G | 2009 | 33 |
| HEV genotypes (11 members) | First IRP (8578/13) | Viremic plasma donations and stool samples diluted in pooled human plasma; HEV genotypes 1a, 1e, 2a, 3b, 3c, 3e, 3f/l, 3 ra, 4c, and 4g | 2015 | 35 |
| HIV-1 subtypes (10 members) | Second IRP (12/224)b | Cultured and heat-inactivated HIV-1 subtypes A, B, C, D, AE, F, G, AG-GH, N, and O diluted in human plasma | 2012 | 31 |
| HIV-1 circulating recombinant forms (10 members) |
First IRP (13/214) | Cultured and heat-inactivated HIV-1 CRFs and subtype variants diluted in pooled human plasma | 2013 | 32 |
| B19V genotypes (4 members) | First IRP (09/110; CBER B19V genotype panel 1) | Viremic plasma donations diluted in pooled human plasma; B19V genotypes 1a1, 2, and 3a and negative plasma control | 2009 | 34 |
a
Sequence details for IRP members are available in the supplemental material. CRF, circulating recombinant forms.
b
The second HIV-1 IRP consists of the same strains as the first IRP; strains included in the first IRP were not subjected to head inactivation.