FIG 3.

Characteristics and outcomes of the IBSM study. (A) Time course of parasitemia and malaria antigens from days 0 through 11 in volunteers inoculated with P. falciparum parasites. Antigen concentration and parasitemia were plotted as the means of measurements of specimens from 16 individuals for each time point. The dotted lines indicate cutoff values, namely, 2.3 pg/ml for HRP2 and 47.8 pg/ml for pan LDH. (B) Relationship between parasitemia and concentration of malaria proteins from specimens. Samples that were positive by qPCR, and the 4-plex array for HRP2 (left), and pan LDH (right) are presented. The R² values were found to be 0.241 and 0.853 for HRP2 (n = 178) and pan LDH (n = 56), respectively. (C) Distributions of parasitemia levels for antigen-positive specimens out of 238 samples for HRP2 (left) and pan LDH (right).