Table S1.
Univariate analysis of esophageal lesions risk factors
| Precursor lesions
|
Premalignant/malignant lesions
|
Reflux esophagitis
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95%CI | P | OR | 95%CI | P | OR | 95%CI | P | |
| Age (years) | <0.001 | <0.001 | 0.002 | ||||||
| 41–50 vs ≤40 | 1.59 | (0.98, 2.78) | 1.06 | (0.38, 4.44) | 1.24 | (0.94, 1.66) | |||
| 51–60 vs ≤40 | 2.42 | (1.48, 4.23) | 3.76 | (1.38, 15.48) | 1.52 | (1.14, 2.05) | |||
| >60 vs ≤40 | 3.36 | (1.80, 6.46) | 10.87 | (3.61, 46.90) | 1.56 | (1.03, 2.34) | |||
| Gender | <0.001 | 0.009 | <0.001 | ||||||
| Female vs Male | 0.62 | (0.50, 0.79) | 0.54 | (0.32, 0.86) | 0.23 | (0.19, 0.28) | |||
| Race | 0.614 | 0.174 | 0.834 | ||||||
| Others vs Han | 0.71 | (0.11, 2.29) | 3.21 | (0.52, 10.58) | 1.09 | (0.47, 2.20) | |||
| Married | 0.273 | 0.986 | 0.344 | ||||||
| Others vs Married | 1.59 | (0.66, 3.25) | 1.02 | (0.06, 4.67) | 0.72 | (0.34, 1.38) | |||
| Education | 0.002 | <0.001 | 0.489 | ||||||
| High school vs College | 1.69 | (1.18, 2.49) | 1.15 | (0.59, 2.46) | 0.94 | (0.77, 1.17) | |||
| Middle school vs College | 1.37 | (0.97, 2.02) | 0.91 | (0.47, 1.94) | 1.03 | (0.84, 1.27) | |||
| Primary school vs College | 2.17 | (1.38, 3.47) | 3.37 | (1.58, 7.60) | 0.89 | (0.65, 1.20) | |||
| Occupation | 0.319 | <0.001 | 0.016 | ||||||
| Peasant vs Worker | 1.13 | (0.48, 2.29) | 3.15 | (0.76, 8.77) | 0.71 | (0.38, 1.23) | |||
| Officer vs Worker | 0.96 | (0.71, 1.28) | 2.34 | (1.37, 3.86) | 1.07 | (0.90, 1.28) | |||
| Service vs Worker | 1.21 | (0.72, 1.92) | 0.44 | (0.02, 2.01) | 0.83 | (0.57, 1.18) | |||
| Retired vs Worker | 1.39 | (1.01, 1.86) | 4.76 | (2.92, 7.61) | 0.83 | (0.65, 1.04) | |||
| Others vs Worker | 1.51 | (0.71, 2.87) | 1.09 | (0.06, 5.07) | 0.38 | (0.16, 0.75) | |||
| Labor intensity | 0.827 | 0.006 | 0.017 | ||||||
| Moderate vs Light | 0.97 | (0.79, 1.19) | 0.59 | (0.37, 0.91) | 1.19 | (1.04, 1.36) | |||
| Heavy vs Light | 0.92 | (0.68, 1.22) | 0.39 | (0.16, 0.80) | 1.21 | (1.01, 1.46) | |||
| Income(¥) | 0.119 | 0.008 | 0.232 | ||||||
| 2,001–3,000 vs ≤2,000 | 0.79 | (0.62, 1.01) | 0.52 | (0.32, 0.84) | 0.98 | (0.83, 1.16) | |||
| 3,001–4,000 vs ≤2,000 | 0.75 | (0.57, 0.98) | 0.44 | (0.24, 0.76) | 1.15 | (0.96, 1.38) | |||
| >4,000 vs ≤2,000 | 0.75 | (0.56, 0.99) | 0.47 | (0.25, 0.84) | 1.01 | (0.83, 1.22) | |||
| Mining exposure | <0.001 | 0.033 | <0.001 | ||||||
| Yes vs No | 1.49 | (1.23, 1.80) | 1.53 | (1.04, 2.29) | 1.95 | (1.72, 2.21) | |||
| Mining exposure time (hours/week) | <0.001 | 0.122 | <0.001 | ||||||
| 1–40 vs 0 | 1.16 | (0.82,1.61) | 1.39 | (0.68, 2.62) | 1.94 | (1.58, 2.37) | |||
| 41–60 vs 0 | 1.53 | (1.23, 1.91) | 1.65 | (1.04, 2.61) | 1.96 | (1.70, 2.28) | |||
| >60 vs 0 | 1.68 | (1.26, 2.21) | 1.67 | (0.89, 2.95) | 1.97 | (1.62, 2.40) | |||
| Dust exposure | 0.002 | 0.299 | <0.001 | ||||||
| Yes vs No | 1.35 | (1.12, 1.64) | 1.23 | (0.83, 1.84) | 1.83 | (1.61, 2.08) | |||
| Gas exposure | 0.003 | 0.610 | <0.001 | ||||||
| Yes vs No | 1.34 | (1.11, 1.61) | 0.90 | (0.60, 1.33) | 1.70 | (1.50, 1.92) | |||
| Smoking | 0.002 | 0.150 | <0.001 | ||||||
| Occasionally vs Yes | 0.82 | (0.55, 1.17) | 1.00 | (0.43, 2.03) | 0.97 | (0.78, 1.20) | |||
| Refrained vs Yes | 1.19 | (0.83, 1.66) | 1.90 | (0.97, 3.48) | 0.91 | (0.72, 1.15) | |||
| Never vs Yes | 0.71 | (0.58, 0.87) | 0.86 | (0.55, 1.33) | 0.41 | (0.36, 0.48) | |||
| Drinking | <0.001 | 0.451 | <0.001 | ||||||
| Occasionally vs Yes | 0.69 | (0.55, 0.87) | 1.08 | (0.66, 1.74) | 0.64 | (0.55, 0.73) | |||
| Refrained vs Yes | 0.67 | (0.53, 0.85) | 0.93 | (0.56, 1.54) | 0.35 | (0.30, 0.42) | |||
| Never vs Yes | 1.38 | (0.85, 2.12) | 2.06 | (0.77, 4.62) | 0.68 | (0.47, 0.96) | |||
| Smoking exposure | 0.016 | 0.333 | <0.001 | ||||||
| Yes vs No | 1.38 | (1.06, 1.84) | 0.79 | (0.50, 1.30) | 1.69 | (1.41, 2.04) | |||
| Smoking time >15 minutes | 0.181 | 0.924 | <0.001 | ||||||
| Yes vs No | 0.87 | (0.70, 1.07) | 0.98 | (0.63, 1.48) | 0.70 | (0.61, 0.81) | |||
| Disease history | 0.816 | 0.188 | 0.010 | ||||||
| No vs Yes | 0.98 | (0.81, 1.18) | 0.77 | (0.52, 1.14) | 0.85 | (0.75, 0.96) | |||
| Heart disease | 0.207 | 0.807 | 0.840 | ||||||
| No vs Yes | 0.82 | (0.61, 1.12) | 0.92 | (0.50, 1.89) | 1.02 | (0.83, 1.27) | |||
| Diabetes | 0.264 | 0.056 | 0.061 | ||||||
| No vs Yes | 1.41 | (0.79, 2.87) | 0.43 | (0.21, 1.02) | 0.73 | (0.53, 1.02) | |||
| Hypertension | 0.502 | 0.033 | <0.001 | ||||||
| No vs Yes | 0.93 | (0.75, 1.16) | 0.63 | (0.42, 0.96) | 0.76 | (0.66, 0.87) | |||
| Digestive disease | 0.816 | 0.292 | 0.225 | ||||||
| No vs Yes | 1.03 | (0.79, 1.36) | 0.76 | (0.47, 1.29) | 1.12 | (0.94, 1.34) | |||
| Respiratory disease | 0.536 | 0.342 | 0.079 | ||||||
| No vs Yes | 0.90 | (0.66, 1.26) | 0.74 | (0.42, 1.42) | 0.83 | (0.68, 1.02) | |||
| Tumor history | 0.827 | 0.879 | 0.821 | ||||||
| No vs Yes | 0.98 | (0.80, 1.20) | 0.97 | (0.64, 1.49) | 1.02 | (0.89, 1.16) | |||
| Other disease history | 0.507 | 0.831 | 0.664 | ||||||
| No vs Yes | 0.91 | (0.71, 1.20) | 0.96 | (0.81, 1.15) | |||||
| Tea consumption | <0.001 | 0.038 | <0.001 | ||||||
| No vs Yes | 1.80 | (1.33, 2.50) | 0.60 | (0.39, 0.97) | 0.75 | (0.64, 0.87) | |||
| Eating postures | 0.644 | 0.069 | 0.463 | ||||||
| Sit vs Squat | 0.91 | (0.47, 2.04) | 0.80 | (0.25, 4.87) | 1.34 | (0.80, 2.40) | |||
| Stand vs Squat | 1.93 | (0.27, 8.65) | 0.73 | (0.88, 68.48) | 0.87 | (0.13, 3.47) | |||
| High temperature food intake | 0.095 | 0.561 | 0.511 | ||||||
| No vs Yes | 1.18 | (0.97, 1.43) | 1.13 | (0.76, 1.69) | 0.96 | (0.85, 1.09) | |||
| Fast eating | 0.238 | 0.631 | 0.087 | ||||||
| No vs Yes | 1.12 | (0.93, 1.35) | 0.91 | (0.61, 1.34) | 0.90 | (0.79, 1.02) | |||
| Salted food consumption | 0.449 | 0.654 | 0.544 | ||||||
| Rarely or Never vs Yes | 0.93 | (0.77, 1.13) | 1.10 | (0.73, 1.67) | 0.96 | (0.85, 1.09) | |||
| Fried food consumption | 0.103 | 0.270 | <0.001 | ||||||
| Rarely or Never vs Yes | 0.84 | (0.68, 1.04) | 0.78 | (0.52, 1.22) | 0.79 | (0.69, 0.91) | |||
| Chilli food consumption | 0.295 | 0.187 | 0.724 | ||||||
| Rarely or Never vs Yes | 1.12 | (0.91, 1.40) | 1.36 | (0.86, 2.24) | 0.98 | (0.85, 1.12) | |||
| Moldy food consumption | 0.751 | 0.83 | 0.916 | ||||||
| No vs Yes | 1.20 | (0.44, 4.94) | 0.80 | (0.17, 14.18) | 1.04 | (0.54, 2.26) | |||
| Leek food consumption | 0.339 | 0.535 | 0.702 | ||||||
| Rarely or Never vs Yes | 0.88 | (0.66, 1.15) | 0.97 | (0.81, 1.15) | |||||
| Bean food consumption | 0.177 | 0.701 | 0.334 | ||||||
| Rarely or Never vs Yes | 0.83 | (0.63, 1.08) | 0.90 | (0.50, 1.51) | 0.92 | (0.77, 1.09) | |||
| Meat/egg/milk consumption | 0.359 | 0.223 | 0.115 | ||||||
| Rarely or Never vs Yes | 0.83 | (0.54, 1.22) | 0.56 | (0.17, 1.35) | 0.81 | (0.62, 1.05) | |||
| Dry food consumption | 0.133 | 0.198 | 0.404 | ||||||
| Rarely or Never vs Yes | 1.17 | (0.95, 1.43) | 1.32 | (0.87, 2.05) | 1.06 | (0.93, 1.20) | |||
| Maize consumption | 0.177 | 0.075 | 0.530 | ||||||
| Rarely or Never vs Yes | 1.14 | (0.94, 1.38) | 1.43 | (0.96, 2.12) | 1.04 | (0.92, 1.18) | |||
| Fresh vegetable consumption | 0.036 | 0.316 | 0.213 | ||||||
| Rarely or Never vs Yes | 10−6 | (10–38, 0.22) | 10−6 | (10−59, 526.04) | 0.50 | (0.12, 1.41) | |||
| Fresh fruit consumption | 0.143 | 0.090 | <0.001 | ||||||
| Rarely or Never vs Yes | 1.15 | (0.95, 1.39) | 1.40 | (0.95, 2.10) | 1.45 | (1.28, 1.65) | |||
| Sauerkraut consumption | 0.288 | 0.667 | 0.656 | ||||||
| No vs Yes | 1.16 | (0.88, 1.56) | 0.89 | (0.53, 1.57) | 0.96 | (0.81, 1.45) | |||
| Water source | 0.839 | 0.481 | 0.316 | ||||||
| Natural vs Others | 1.04 | (0.67, 1.55) | 1.34 | (0.56, 2.70) | 1.15 | (0.87, 1.49) | |||
| Foreign residency | 0.017 | 0.137 | 0.483 | ||||||
| No vs Yes | 0.60 | (0.41, 0.91) | 0.53 | (0.26, 1.26) | 0.89 | (0.66, 1.23) | |||