Table 3.
Association between NEK2 expression and clinicopathological features
| Clinicopathological parameters | Studies (n) | Patients (n) | OR (95% CI) | P-value | Heterogeneity
|
|
|---|---|---|---|---|---|---|
| I2 (%) | P-value | |||||
|
| ||||||
| Age (≥65 vs <65 years) | 3 | 403 | 0.45 (0.11–1.84) | <0.00001 | 96 | 0.27 |
| Gender (male vs female) | 12 | 2,150 | 3.02 (1.30–7.02) | 0.01 | 97 | <0.00001 |
| Clinical stage (I–II vs III–IV) | 6 | 1,086 | 2.50 (0.78–8.03) | 0.13 | 97 | <0.00001 |
| Tumor differentiation (well/moderate vs poor) | 5 | 625 | 4.23 (1.30–13.77) | <0.00001 | 95 | <0.00001 |
| Tumor nodule number (solitary vs multiple) | 4 | 682 | 5.88 (2.19–5.80) | 0.0004 | 93 | <0.00001 |
| Tumor size (≥5 vs <5 cm) | 3 | 602 | 1.07 (0.16–7.31) | 0.95 | 98 | <0.00001 |
| Venous invasion (present vs absent) | 3 | 667 | 6.55 (0.86–49.59) | 0.07 | 98 | <0.00001 |
Abbreviation: NEK2, NIMA-related kinase 2.