Table 1.
Pathways analysis of transcriptomic data associated with liver fibrosis progression in diethylnitrosamine (DEN) model.
| Pathway ID | Pathway term | DifGene | P-value | FDR | Enrichment |
|---|---|---|---|---|---|
| PATH:04510 | Focal adhesion | 77 | 2.12173E-11 | 5.41040E-09 | 2.683956267 |
| PATH:04060 | Cytokine-cytokine receptor interaction | 83 | 2.79329E-09 | 2.37430E-07 | 2.268450051 |
| PATH:04151 | PI3K-Akt signaling pathway | 100 | 5.46857E-09 | 3.48622E-07 | 2.06151743 |
| PATH:04512 | ECM-receptor interaction | 38 | 1.14008E-07 | 4.84534E-06 | 3.080694586 |
| PATH:04380 | Osteoclast differentiation | 47 | 1.33927E-07 | 4.87876E-06 | 2.670233206 |
| PATH:05205 | Proteoglycans in cancer | 68 | 2.33252E-07 | 6.65913E-06 | 2.170978532 |
| PATH:05200 | Pathways in cancer | 89 | 2.35038E-07 | 6.65913E-06 | 1.951862247 |
| PATH:04014 | Ras signaling pathway | 68 | 3.03188E-07 | 7.73129E-06 | 2.151934861 |
| PATH:04810 | Regulation of actin cytoskeleton | 66 | 3.71753E-07 | 8.61792E-06 | 2.164593301 |
| PATH:04360 | Axon guidance | 48 | 4.65484E-07 | 9.89154E-06 | 2.530743412 |
| PATH:04670 | Leukocyte transendothelial migration | 44 | 5.67287E-07 | 1.11275E-05 | 2.602243313 |
| PATH:04514 | Cell adhesion molecules (CAMs) | 52 | 7.02364E-07 | 1.27931E-05 | 2.359724354 |
Note: Axon guidance signaling are listed within the significantly upregulated signaling pathways (partial).