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. Author manuscript; available in PMC: 2019 Jan 7.
Published in final edited form as: J Expo Sci Environ Epidemiol. 2016 Dec 7;27(6):618–624. doi: 10.1038/jes.2016.68

Table 2.

Results for exposure scenarios described in text.

Exposure scenario Nicotine formulation Exposure Area (cm2) mT(mg) mT* (mg) C (ng/ml)
1 Neat nicotine All fingers, immersion 73 — 99.7 (29.9) 184
Thumb and index, immersion 35 — 47.8 (14.3) 88.3
Lemon-Lime eJuice All fingers, immersion 73 4.02 21.4 (6.42) 24.9
Thumb and index, immersion 35 1.93 10.3 (3.09) 12.0
2 Lemon-Lime eJuice 1 ml spread over skin 154 7.51 — 52.6
3 Lemon-Lime eJuice 5 ml spread over skin 769 37.5 — 263
15 ml spread over skin 2307 112 — 789

mT, total mass of nicotine systemically absorbed from exposures to the specified formulation. C is plasma nicotine concentration, calculated from Eq. (8) assuming steady-state fluxes listed in Table 1. Scenario 1 assumes 4 h exposure followed by washing; others assume 48 h finite dose exposures. mT* are model-based transient exposure estimates, as described in the text. Surface areas for Scenario 1 are the volar surface areas of the specified digits of both hands.