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. Author manuscript; available in PMC: 2019 Jan 7.
Published in final edited form as: J Neurosurg. 2013 Jul 12;119(3):766–773. doi: 10.3171/2013.6.JNS13135

Fig. 4.

Fig. 4.

Combined treatment with subeffective doses of lithium and VPA improved beam-walk performance after TBI. The beam-walk test was performed 1, 3, 7, 14, and 21 days after injury to assess motor coordination. TBI markedly increased the number of foot faults in all groups examined. A slow recovery from 7 to 21 days postinjury was seen in all groups. Compared with the saline-treated group, a significant reduction in the number of foot faults was observed in the combined treatment group 7, 14, and 21 days after injury (n = 8/group for all drug treatment groups; n = 6/group for the sham and saline groups; *p < 0.05; ***p < 0.001). Treatment with VPA alone did not affect the number of foot faults at any time point, whereas the lithium-treated group showed a reduced number of foot faults compared with the saline-treated group on Days 14 and 21 after injury.